Prolonged vs Short Courses of Antibiotic Prophylaxis after Oral and Maxillofacial Surgery
Evaluation of Prolonged vs Short Courses of Antibiotic Prophylaxis Following Ear, Nose, Throat, and Oral and Maxillofacial Surgery:
A Systematic Review and Meta-Analysis
From a study published on JAMA Network Open,
May 29, 2019, by
Question Is there a difference in outcome associated with a short course of antibiotic prophylaxis (≤24 hours) vs an extended course of antibiotic prophylaxis (≥72 hours) for preventing surgical site infections after ear, nose, throat (ENT), and oral and maxillofacial (OMF) surgery?
Findings In this systematic review and meta-analysis, which included 21 articles and 1974 patients, no significant differences were found in the relative risks of developing surgical site infections after receiving short-course antibiotic prophylaxis vs extended-course antibiotic prophylaxis.
Meaning These findings suggest that short-course antibiotic prophylaxis should be used for standard ENT and OMF surgery, unless there are documented conditions that would be best treated with an extended course.
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Oppelaar MC, Zijtveld C, Kuipers S, et al. Evaluation of Prolonged vs Short Courses of Antibiotic Prophylaxis Following Ear, Nose, Throat, and Oral and Maxillofacial Surgery: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. Published online May 09, 2019145(7):610–616. doi:10.1001/jamaoto.2019.0879